Head of Medical Affairs

<p>Remix launched with a vision to transform patients’ lives through modulation of RNA processing. Our breakthrough science enables the identification of small molecules that influence the expression of disease‑driving mRNAs and proteins. We focus on diseases of high unmet medical need and are committed to operating with scientific rigor and urgency. With a proprietary in‑house technology platform, we have rapidly generated multiple discovery programs advancing toward the clinic. Remix Therapeutics was recognized as one of BioSpace’s Best Places to Work in Boston 2025 and is backed by leading life sciences investors.</p>
<p><strong>Position Summary:</strong></p>
<p><span data-contrast="none">Remix is seeking a Head of Medical Affairs to provide medical affairs leadership for REM-422 and contribute to the development of future programs across the portfolio. REM-422 is an innovative investigational therapy targeting RNA splicing machinery, with adenoid cystic carcinoma (ACC), a rare salivary gland cancer, as its first clinical indication. With no approved therapy for ACC, this is an opportunity to help shape the medical and treatment landscape for patients with a rare cancer while playing a key role in advancing a novel therapeutic approach.</span><span data-ccp-props="{"335559739":130}"> </span></p>
<p><span data-contrast="auto">Reporting directly to the Chief Medical Officer and based at our Watertown, MA headquarters, this individual will play a central role in disease education, scientific leadership, external engagement, evidence generation and trial execution, and interpretation of emerging clinical data. This is the first medical affairs hire at Remix. You will define what the function is, hire the people who follow you, and grow the organization as REM-422 moves toward approval and launch.  You will also be the external scientific voice of the company, personally engaged in the field with KOLs and advocacy leaders. The role is global in scope; however, the United States is the initial focus and the first launch market.</span><span data-ccp-props="{"335559739":130}"> </span></p>
<p><strong>Key Responsibilities:</strong></p>
<p><strong><span data-contrast="auto">Disease Education and Market Definition</span></strong><span data-ccp-props="{"335559738":170,"335559739":70}"> </span></p>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="none">Lead development and execution of Medical Strategy with a focus on REM-422 for use in ACC.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Build scientific awareness of ACC as a MYB driven disease across medical oncology, head and neck, and ENT communities, and establish Remix as a credible scientific voice in the field.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Work with other key stakeholders to map the ACC patient journey: where patients present, who they see, how they are referred, and where they fall out of the system.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto">Advance understanding of MYB biomarker testing so eligible patients can be identified, partnering with Clinical Development, Regulatory, and diagnostic partners.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto">Generate and codify real world insight on current management patterns and unmet need and feed it into development and launch planning.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Scientific Leadership and External Engagement</span></strong><span data-ccp-props="{"335559738":170,"335559739":70}"> </span></p>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto">Personally engage leading ACC, head and neck, and hematology investigators, and build the KOL network.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="7" data-aria-level="1"><span data-contrast="auto">Oversee advisory boards, congress strategy, and scientific exchange that shape how ACC is defined and treated.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="8" data-aria-level="1"><span data-contrast="auto">Build durable partnerships with ACC advocacy organizations and bring the patient's voice into development and launch decisions.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="9" data-aria-level="1"><span data-contrast="auto">Represent Remix externally in scientific and business development settings.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Evidence Generation and Communication</span></strong><span data-ccp-props="{"335559738":170,"335559739":70}"> </span></p>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="10" data-aria-level="1"><span data-contrast="auto">Own publication strategy and execution across ACC and AML/HR-MDS.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto">Direct the HEOR, natural history, burden of disease, and real-world evidence to work that a disease with no approved therapy leaves undone.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="12" data-aria-level="1"><span data-contrast="auto">Run the investigator sponsored trial program and provide medical insight into company sponsored trial design, endpoints, and lifecycle strategy.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Launch Readiness and Cross-Functional Partnership</span></strong><span data-ccp-props="{"335559738":170,"335559739":70}"> </span></p>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="13" data-aria-level="1"><span data-contrast="auto">Partner with Clinical Development, Regulatory, and Commercial on launch preparation, contributing to the medical and scientific perspective.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="14" data-aria-level="1"><span data-contrast="auto">Ensure the clinical evidence base is accurately understood across the organization so that planning rests on what the data actually supports.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="15" data-aria-level="1"><span data-contrast="auto">Provide an independent medical review of educational and promotional material and set the standard for scientific accuracy.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1"><span data-contrast="auto">Coordinate field medical planning with commercial field planning, so coverage is complementary, and we act as one Remix team in all external interactions.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="17" data-aria-level="1"><span data-contrast="auto">Inform market access strategy through the burden of disease and health economics evidence.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<p><span data-ccp-props="{"335559739":80}"> </span><strong><span data-contrast="auto">Building the Function</span></strong><span data-ccp-props="{"335559738":170,"335559739":70}"> </span></p>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="18" data-aria-level="1"><span data-contrast="auto">Design and stand-up field medical, medical information, and medical communications, making clear build versus outsource decisions and owning the budget.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="19" data-aria-level="1"><span data-contrast="auto">Hire and lead a small, seasoned team that operates ahead of its headcount, and set the plan for how the function scales through approval and into launch.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="20" data-aria-level="1"><span data-contrast="auto">Establish medical affairs policies, SOPs, and review processes consistent with the principles of scientific engagement, and partner with Legal and Compliance to keep all activity within Remix policy and applicable law.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="21" data-aria-level="1"><span data-contrast="auto">Own the medical governance of expanded access and compassionate use requests, and the escalation pathway between medical information and Pharmacovigilance.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<p><strong>Qualifications:</strong></p>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="22" data-aria-level="1"><span data-contrast="auto">Advanced life science degree required. MD or equivalent medical degree preferred; PhD or PharmD considered.</span><span data-ccp-props="{"134233117":true,"134233118":true,"335557856":16777215}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto">10+ years in medical affairs and prior leadership of the function.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="24" data-aria-level="1"><span data-contrast="auto">Oncology experience is required. Solid tumors strongly preferred; head and neck or salivary gland is a distinct advantage.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="25" data-aria-level="1"><span data-contrast="auto">Built a Medical Affairs function from an early state rather than only running an established one.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="26" data-aria-level="1"><span data-contrast="auto">Launch experience preferred, ideally with a first in class or first in disease product where the treatment pathway had to be established.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="27" data-aria-level="1"><span data-contrast="auto">Existing relationships across oncology academic institutions. </span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="28" data-aria-level="1"><span data-contrast="auto">Global perspective preferred, including working knowledge of the European medical affairs and regulatory environment or experience supporting ex-US capability.</span><span data-ccp-props="{"335559739":80}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="29" data-aria-level="1"><span data-contrast="auto">Excellent written and verbal communication skills, including experience authoring or reviewing scientific and medical content for external audiences.</span><span data-ccp-props="{"134233117":true,"134233118":true,"335557856":16777215}"> </span></li>
</ul>
<ul>
<li data-leveltext="•" data-font="Calibri" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":403,"335559991":244,"469769242":[8226],"469777803":"left","469777804":"•","469777815":"hybridMultilevel"}" data-aria-posinset="30" data-aria-level="1"><span data-contrast="auto">Demonstrated ability to operate effectively in a highly collaborative, cross-functional, and fast-paced biotechnology environment.</span><span data-ccp-props="{"134233117":true,"134233118":true,"335557856":16777215}"> </span></li>
</ul>
<p><strong>Salary Range</strong></p>
<p><span class="TextRun SCXW219381972 BCX0" lang="EN-US" data-contrast="none"><span class="NormalTextRun SCXW219381972 BCX0">$293,000 - $415,000 </span><span class="NormalTextRun SCXW219381972 BCX0">USD</span></span><span class="EOP SCXW219381972 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":60,"335559739":60,"335559740":259}"> </span></p>
<p>This range reflects the expected base salary for this position, plus bonus, equity, and benefits as applicable.  Actual salaries may vary based on factors, such as skill, experience, and qualification for the role.</p>
<p> </p>