Principal Clinical Data Manager

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Principal Clinical Data Manager based in Canada.

This role offers an opportunity to provide senior-level clinical data management leadership across complex clinical research programs. You will oversee data management activities from study start-up through database lock, ensuring high standards of data quality, accuracy, and documentation. Working across mid-to-large and multi-study programs, you will lead teams of Clinical Data Managers and coordinate delivery against project requirements. The position combines hands-on expertise with program-level oversight, strategic guidance, and cross-functional collaboration. You will also help strengthen operational consistency, resource planning, and the adoption of data management best practices. As a senior subject matter expert, you will mentor colleagues and contribute to training initiatives across clinical research functions.

Accountabilities

• Lead clinical data management activities from study start-up through database lock across paper-based and electronic data capture (EDC) studies.
• Take overall responsibility for data quality, documentation, and the successful delivery of data management activities for assigned clinical research projects.
• Manage mid-to-large, complex projects across a range of therapeutic indications and, when required, oversee multiple studies within the same client program.
• Lead teams of Clinical Data Managers and ensure contracted activities are delivered in accordance with applicable standard operating procedures and sponsor-specific requirements.
• Partner with Data Management leadership to promote consistent operations, efficient resource utilization, and the sharing of knowledge and best practices.
• Provide technical and project leadership, supporting teams in resolving challenges and achieving mutually agreed outcomes.
• Support the training and development of data managers on project-specific and general data management processes, procedures, and systems.
• Provide data management training and expertise to other functional teams when required.
• Act as a senior consultant and thought partner to management, providing guidance with a broader program and organizational perspective.

Requirements

Bachelor’s degree in a related field with 7+ years of relevant experience, including at least 5 years of clinical data management experience in a clinical research environment.

At least 4 years of experience leading project teams.

Thorough knowledge of ICH Good Clinical Practice (GCP) guidelines and other applicable regulatory requirements and standards.

Strong understanding of medical terminology, clinical trials, and clinical research processes.

Working knowledge of the CRO industry and its regulatory and operational relationship with pharmaceutical and biotechnology organizations.

Demonstrated ability to lead by example and provide effective technical leadership and mentorship to team members.

Strong consulting and influencing skills, with the ability to influence without authority and guide diverse project teams toward effective outcomes.

Ability to think strategically and maintain a big-picture perspective while addressing project-level priorities.

Expert-level proficiency with clinical trial databases and applications, such as IBM Clinical Development and Medidata RaveX, combined with the ability and willingness to learn new technologies.

Strong understanding of project planning and project management methodologies.

Excellent interpersonal, communication, organizational, and prioritization skills.

Ability to work independently and collaboratively across multiple projects with different priorities.

Strong mentoring capabilities and the ability to provide senior-level clinical data management expertise.

Benefits

• Estimated hiring range of $114,000–$150,000 USD plus applicable bonus; compensation outside the USA varies according to local market data.
• Final compensation considers skills and experience, licensure and certifications, education, location, and current market conditions.
• Remote working opportunities.
• Flexible time off.
• Paid holidays.
• Medical insurance.
• Tuition reimbursement.
• Retirement plans.
• Opportunity to work within a global clinical research environment supporting life-changing therapies.
• Exposure to complex clinical research programs across diverse therapeutic areas.
• Inclusive and flexible work culture with a predominantly remote workforce.
• Opportunities to contribute to knowledge sharing, mentoring, and professional development.