About The Role

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description

Wave Life Sciences, an oligonucleotide therapeutics company, seeks a highly motivated co-op student to join its team of scientists in Lexington, Massachusetts. The co-op student will gain exposure to the areas of oligonucleotide synthesis, chromatographic purification, tangential flow filtration (TFF) and analysis. Co-ops will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity. This is an ideal position for any student, including those looking for their first co-op, with strong organizational skills and attention to detail who thrive in a team-oriented, fast-paced, and cross-disciplinary biotech environment. Organic chemistry or Biochemistry laboratory experience is preferred.

Responsibilities

Reagent preparation & column packing for Oligo synthesis
Buffer preparation, cleaning and sanitization of equipment used to manufacture oligonucleotides
Purification of oligonucleotides
Oligonucleotide synthesis preparation and handling of amidites
Oligo quantitation using spectrophotometers
Tangential Flow Filtration of purified oligos
Operation of automated oligonucleotide synthesizers, purifiers, tangential flow filtration (TFF) systems and Lyophilizers
Analysis of oligonucleotide samples by UPLC and LC-MS
Using excel spreadsheets for data processing, analysis, and interpretation
Documentation of lab experiments in an electronic notebook (ELN)
Batch record review
Inventory maintenance

Key Skills and Competencies

Strict adherence to lab safety protocols including PPEs.
Effective communication skills and ability to present experimental results at group meetings

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.