Manager, Protein Biology

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

About the company

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $44 billion. Our Mission is to enable our customers to make the world healthier, cleaner, and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing efficiency in their laboratories, improving patient health through diagnostics, or developing and manufacturing life-changing therapies, we are here to support them. Our distributed team delivers an outstanding combination of innovative technologies, purchasing convenience, and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. Our Innovative Laboratory technologies & Services makes it easier for customers.

About Team: Antibody team

The antibody team is involved in development and engineering of antibodies, with a deep focus on reagent quality and specificity. The core activities of team include design, development, purification, conjugation and testing of antibodies in a variety of immunoassay applications using current tools and technologies. The goal of the program is sophisticated product development and creation of product specific information to promote research use.

Role & Responsibilities

Role

To be an integral part of an antibody development team with a focus on performance and specificity using innovative molecular, protein, and cell biology methods. The successful candidate will be joining the Bangalore R&D leadership team in developing products and solutions for discovery, validation and characterization of antibodies for the Thermo Fisher Scientific product portfolio. The candidate should be well versed with recombinant antibody development using state-of-art technology. This position involves people management, multi-disciplinary internal, external and cross function collaboration to drive execution of R&D projects.

Responsibilities

• Contribute in a fast- paced environment towards antigen and antibody development and purification
• R&D Manager role in new antibody development projects using single B cell sorting or phage display technology, with vast experience in experimental planning and execution to meet the program schedule
• Manage a team of scientists in matrix style operation, provide technical and operational supervision.
• Good scientific writing skills, establishing technical protocols for effective transfer to operation teams.
• Mentoring and training junior scientists in research, designing and experimental execution, interpreting data and data presentation to the stakeholders
• Good documentation practice is a must to maintain data integrity and accuracy.
• Delivering high quality results according to project schedule in support of product commercialization from concept to launch including early feasibility, development and validation phases.
• Support the manufacturing team for technical support and quality by providing technical guidance.

Candidate Requirement

Education & Experience levels

Applicants should have a Ph.D in Biotechnology/Life Sciences or related subject area with over 10 years relevant experience. Minimum 3-4 years of industrial experience and people management experience is required.

Nature of experience

• Experience with antibody development, engineering, reformatting and purification including hybridoma, single B cell, phage or yeast display and other recombinant antibody platforms
• Expert in the field of peptide and protein design, expression, purification, and protein-protein interaction (Structure -function -relationship)
• Thorough understanding of antigen/immunogen properties, design and development towards eliciting desired antibody response
• Extensive experience in expression and purification of recombinant antibodies, their formats and other recombinant proteins from bacterial, yeast, insect and mammalian systems
• Extensive experience in structural biology, antibody and protein engineering, computational modeling and rational design. Understanding of current technology trends and use of AI/ML in antibodies or protein design is an advantage
• Expertise in development of conjugation chemistries or performing antibody conjugations is desired
• Broad knowledge and experience in molecular biology, cell biology, immunoassays, protein design, engineering, purification, and conjugation fields to enable successful delivery on program goals
• Thorough in biochemical and immunoassay workflows such as ELISA, SDS-PAGE, Western blotting, IF, IHC
• Thorough in biochemical and biophysical workflows such as recombinant protein expression and purification, antibody characterization using SPR or BLI.
• Ability to provide technical trouble shooting to resolve scientific problems.
• Authorship of peer-reviewed publications with post-doctoral experience and a strong, independent understanding of standard and emerging research protocols and techniques are preferred. GLP experience is a must.
• Experience in authoring and optimizing standard operating procedures with a focus on reproducibility
• Skills for identifying deviations from expected outcomes, problem solving and suggesting alternatives
• Excellent written and verbal presentation skills
• Proven leadership skills and ability to work alongside colleagues from different backgrounds
• Demonstrated ability to attract and develop talent, and build a high performing team

The successful candidate will be self-motivated and a self-starter who is excellent at learning and applying new concepts for process or product improvements, possess excellent oral and written communication skills to connect to peers and leadership, and will be an excellent teammate with the ability to work with diverse colleagues.

Thermo Fisher Scientific is an equal opportunity employer and value diversity at our company. All qualified applicants will receive consideration for employment without discrimination basis race, color, religion, sex, sexual orientation, gender, gender identity or expression, national origin, protected veteran status, age, genetics, pregnancy, disability or any other legally protected status. Thermo Fisher Scientific aligns with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!

Thermo Fisher Scientific is committed to crafting a diverse work environment that values and respects individuals from all backgrounds. Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.