Senior Principal Scientist, Medicinal Chemistry

• Let’s build the future of medicine—together.
• Senior Principal Scientist, Medicinal ChemistryHyderabad, India | Full-Time

YOUR ROLE

As a Senior Principal Scientist, Medicinal Chemistry at Enveda, you will independently drive lead optimisation programmes — designing novel molecules, interpreting SAR, and shaping drug discovery strategy across multiple programmes. You will work at the intersection of synthetic chemistry, DMPK, biology, and AI-enabled design while mentoring the next generation of medicinal chemists. Reporting to the Director/AVP of Chemistry, your scientific ownership will directly advance our mission to deliver hope to patients everywhere.

WHAT YOU'LL DO

• Independently design novel molecules, interpret SAR/SPR, and generate design hypotheses to drive lead optimisation programmes
• Integrate biology, DMPK, and AI insights into compound design; use AI-enabled molecular design tools to accelerate discovery
• Lead multiple discovery programmes with full scientific ownership and present strategy to cross-functional global teams
• Mentor junior scientists in medicinal chemistry thinking, scientific communication, and decision-making
• Ensure compliance with Enveda notebook SOPs, internal IP standards, and database requirements

WHAT WE'RE LOOKING FOR

• PhD in Organic or Medicinal Chemistry from a leading research institution with 12-15 years of medicinal chemistry experience in CRO or integrated drug discovery
• Demonstrated track record of independently driving lead optimisation and delivering preclinical candidates
• Expert practical skills in synthetic organic chemistry, route design, and SAR/DMPK-informed decision-making
• Strong rational drug design experience including novelty evaluation and IP awareness
• Outstanding scientific presentation and communication skills; comfortable representing programmes to global teams
• We hire for trajectory, not just credentials. If you meet most of the above and care deeply about this problem, we want to hear from you.

ABOUT ENVEDA

We're a clinical-stage, AI-enabled biotech discovering medicines four times faster than the industry standard. We recently raised $150M in a Series D, reached unicorn status, and advanced our first drug into Phase 2 trials. Forbes named us one of America's Best Startup Employers. Newsweek recognized us as a Top 100 Most Loved Workplace. We're building something rare and we're just getting started!