About The Role

Physical work location: (must be proper street address) 1468 Madison Avenue, New York NY
Name PI or Supervisor: (include phone and email) Hanna Irie MD, PhD, (212) 241-3720, [email hidden]
Administrative Contact: (phone and email) Randa Hazar, [email hidden]

Details of Research Project

The researcher will be engaged in translational cancer research projects focused on regulators of growth, survival and drug resistance of breast and other cancers, as well as their microenvironment, especially immune effectors. The researcher will use a broad range of approaches (genetic, cell biological and in vivo modeling) to understand how breastcancers, particularly triple negative breast cancers, resist chemotherapy treatments and metastasize. The projects also examine novel mechanisms that contribute to the growth and metastases of triple negative breast cancers. The researcherwill utilize patient-derived xenograft models of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with chemical biologists. The researcher will also study how the immunemicroenvironment regulates response of breast and other cancers to chemotherapy/targeted therapies. The researcher will be expected to design and conduct experiments, be responsible for accurate record keeping and contribute to overallmaintenance of the laboratory.

Background in cancer cell biology/models, genetics, molecular biology, biochemistry, or immunology required. Experience with mouse tumor models and related procedures (handling, tumor cell injection, flow cytometry, mouse surgical procedures, IVIS imaging) strongly preferred

Ph.D or MD/PhDrequired with at least two years of laboratory experience.

Technical Duties: (include any protocols)

-Cell culture

-Western Blot

-Cell viability assays

-qPCR

-DNA preparation (bacterial transformation, DNA extraction, transfection)

-Lentivirus production

-Mouse handling-tumor cell injections, mouse surgeries, IVIS imaging

-Flow cytometry

-Organoid development and culture

-Microscopy

-Lab record keeping

-Contribute to laboratory maintenance

Educational and other Requirements for the position

Minimum B.A./B.S. required with at least two years of laboratory experience. Candidates with M.A./M.S. or other advanced degrees will also be considered.
Experience Required: At least two years of wet bench laboratory experience

Goals/Outcomes of the Research Project

The goals are to develop and validate novel therapeutics targeting novel oncogenes in breast cancer models.

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72,500.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.