Research Associate II, Analytical Chemistry (Contract)

Prolific Machines is ushering in a new era of biotechnology with light. Our mission is to make next-generation therapies broadly available to patients. Our first-of-its-kind Photomolecular Platform uses light to precisely guide how cells produce complex biologics, enabling higher titers, improved quality, and faster development timelines. By helping partners overcome today’s manufacturing bottlenecks, we’re accelerating the delivery of life-changing medicines. Prolific is supported by leading investors, including Bill Gates’s Breakthrough Energy Ventures, Mayfield, and SOSV.

Help us create a brighter tomorrow with biology. We're looking for mission-driven, talented, and kind people to join our team.

Responsibilities

• Plan, execute, and interpret experimentation to understand protein expression, protein quality through cell line, upstream and downstream process development.
• Execute, summarize and interpret routine and complex therapeutic protein characterizations.
• Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs).
• Support the development, optimization, and validation of analytical methods for quantitative and qualitative protein analysis.
• Document experimental procedures, data, and results in high-quality laboratory notebooks in accordance with SOPs and internal standards.
• Coordinate and communicate with stakeholders of multiple experiments.

About You

• Hold a Bachelor’s degree in Chemistry, Biology, Biochemistry or closely related field, with 2+ years of industry experience. Candidates without a degree but with similar industry experience are encouraged to apply.
• Demonstrated experience operating HPLC/UPLC systems for protein therapeutic analysis and interpreting chromatographic data.
• Hands-on experience operating, maintaining, and troubleshooting HPLC/UPLC instrumentation, ideally Agilent systems with OpenLab CDS.
• Familiarity with ICH guidelines and GMP/GxP environments is a plus.
• Familiarity with the development and implementation of CE and cIEF is a plus.
• Excited to work with internal and external clients to deliver project excellence.
• Have strong communication skills and comfortable sharing knowledge at multiple levels of technical detail.