Oligonucleotide Design Lead

Lead the design and computational optimisation of RNA therapeutics, particularly siRNA, integrating RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, including up-regulation strategies. Define and prioritise target sites and design strategies by integrating sequence features, RNA accessibility, transcript structure, cross-species alignment, and emerging experimental data Drive iterative design–test–learn cycles by analysing and rapidly integrating datasets linking sequence, chemistry, and biological activity to inform decision-making Develop and apply computational tools and workflows (e.g. Python or R) to enable scalable oligonucleotide design, data integration, and rapid sequence–chemistry iteration Partner closely with oligonucleotide chemists and delivery scientists to co-optimise sequence, chemical modifications, and delivery approaches to maximise potency, durability, and tissue activity Lead and contribute to discovery programs advancing RNA therapeutic candidates toward candidate profiling and clinical development, while helping prioritise and evaluate new targets aligned with platform capabilities. .

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