Bench Scientist - Synthetic Organic & Medicinal Chemistry, Drug Discovery Research (Ph. D Candidate Only)

Areas(%of time) KeyAccountabilities/ Responsibilities Designand Synthesis Key Responsibilities: · Basic understanding of setting-up & executing reactions in the laboratoryforsynthesisofNCEsbyfollowingsafetyprotocolsand synthetic routes. · Understand the safety protocols, wear appropriate PPE and other safety required equipment, follow the MSDS (Material Safety Data Sheet) and discuss with supervisor/lab head as well as team members before executing the reactions. · Conduct literature search, plan the synthetic route and execute the reactions with proper reagents, solvents and equipment (glassware, stirrers, rotary evaporators, vacuum pumps etc.,) while maintaining certain reaction conditions (temperature – cooling/heating/regular). · Monitor the progress of the reaction using standard methods and various analytical chemistry techniques (TLC, GC, LCMS, HPLC etc.,) · Identify and execute appropriate work-up and purification (chromatographic techniques) to produce an intermediate/final NCEs with desired purity/quality. · Meet the productivity benchmark (Number of reactions/number of steps/number of NCEs, quantity, quality/purity of compounds) and timelines. · Archive of samples to compound library as per departmental guidelines. Analytical skill · Characterizetheintermediate/finalNCEsthroughanalyticalmethods (NMR,Massspectrometry,IR,UV,HPLCetc.,)andinterprettheresults. · Accurately document all the reactions performed (experimental procedures/protocols,reactionprogress,keyobservations,work- up, purificationandanalyticalcharacterizationetc.,)intheLabNote Book Documentation and presentation (Hand-written /Electronic). · Preparefinalreportsasandwhen required. · Maintain the records, data integrity and follow strict IP & confidentiality. Crossfunctional coordination · Abilitytoworkin ateam environment. · Know all relevant stake holders, their role, function and requirements. Effective communication and coordination with relevant stake holders for sample submission as per departmental guidelines and providing information, well within time lines. Training,Coachingand Mentoring · Improve knowledge of synthetic organic chemistry and analytical techniques through regular discussion with supervisor, attending weekly/biweekly progress update meetings, group meetings, class room training/seminars etc. · Learn new techniques and technologies used in the chemistry domain for efficiency (Eg. Parallel execution of multiple reactions, microwave chemistry). ResourcePlanning, utilization and Management · Ensuresafetyatworkthroughenforcementofgoodlaboratory practices and follow safety and quality systems in the laboratory. · Maintain and use the equipment/instruments as per SOP and general housekeeping norms. Internal Nature Coordinationwithother Chemist Abletoeffectivelyplanandutilizeavailableresourcesincosteffective manner. Capabletomobilizeresourceswithinandoutside groups. Capabletoforeseefuturerequirementandcapacity planning. External Nature Coordination with external stake holderslikeAR,CMC,invitro,invivo, IP, store, GDSO & DMPK team. Training,CoachingandMentoringtoimproveknowledgeandcomplete given task successfully and effectively. Effectivecoordinationwithallstakeholderstoensuretheproject progress and overall productivity Key Dimensions Financial Dimensions · The bench scientist will be executing synthetic organic chemistry reactionsinthelaboratoryandwillbesynthesizingnewchemicalentities (NCEs) for Medicinal chemistry, drug discovery research.